March 8, 2021

Victory in the fight against multiresistant bacteria to antibiotics

French researchers have managed to develop two new antibiotics that do not trigger resistance when used in mice which would mean new possibilities as they are not only effective against gram-positive multiresistant bacteria (those bacteria that stain dark blue or violet by Gram stain) and negative, but they suppose a new impulse and new possibilities to fight the resistance to the antibiotics in all the world. Antibiotics, considered one of the most important scientific advances in contemporary medicine, have met with the growing resistance they generate in the body and that makes them gradually ineffective, which is a problem for public health in the long term. The few antibiotics that are released to the market are neither more nor less than derived from the existing ones.

Professor Brice Felden and his team in the laboratory Inserm and Universitè de Rennes 1 together with another from the Institute of Chemistry of Rennes Sciences (ISCR) have recently identified a bacterial toxin that they have managed to transform into powerful active antibiotics against bacteria responsible for human infections. "It all started in 2011 with a fundamental discovery when we realized that the toxin produced by "Staphylococcus aureus", whose function is to facilitate infection, can also kill other bacteria in our body "explains Brice Felden, director of the Regulatory Medicine Laboratory of RNA and Bacterial Medicines in Rennes. "We thought that if we could separate the activities, we could create a new antibiotic that is not toxic to the body. A challenge that we accept ».

The team with members of ISCR chemistry Michèle Baudy Floc'h They synthesized a new family of so-called peptidomimetics, which are inspired by natural bacterial peptides existing, but shortened and modified. Of the twenty molecules created, two of them proved to be effective against the resistant "Staphylococcus aureus" and "Pseudomonas aeruginosa" in models of mice with severe sepsis or skin infection. After several days in contact of the bacteria with animals did not show resistance to these antibiotics. To advance further in the research, they created favorable conditions for the development of resistance in vitro and in vivo, without anything happening.

"We believe that these new molecules are promising candidates for the development of new antibiotics that can provide alternative treatments to antimicrobials," study authors point out.

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