May 11, 2021

Some Chinese scientists manage to clone monkeys genetically

Some Chinese scientists manage to clone monkeys genetically

The first cohort of five monkey clones genetically engineered from a monkey's fibroblasts with disease phenotypes was recently born at the Neuroscience Institute (ION) of the Chinese Academy of Sciences (CAS) in Shanghai, China.

For the experiment, the expression of BMAL1, a central circadian regulator transcription factor, was eliminated in the donor monkey using the gene editing mediated by CRISPR / Cas9 in the embryo stage, and the donor monkey fibroblasts were used to clone five monkeys using the somatic cell transfer method, the same method that Zhong Zhong and Hua Hua, the first two cloned monkeys, generated last year.

This important advance, which is detailed in two articles published in the digital edition of this Thursday in the magazine 'National Science Review', shows that a population of personalized macaque monkeys edited by genes with a uniform genetic background for biomedical research will soon be available.


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