The patients who consume cannabis They may regularly need more than twice the usual level of sedation when they undergo medical procedures, according to a study conducted by researchers in Colorado (USA). The study, published in The Journal of the American Osteopathic Association, examined more than 250 medical records of patients who received endoscopic procedures after 2012, when the State of Colorado legalized recreational cannabis.
The result was that patients who smoked or ingested cannabis daily or weekly required 14% more fentanyl, 20% more midazolam and 220% more propofol to achieve optimal sedation in routine procedures, including colonoscopy . Internal medicine's osteopathic physician and lead researcher Mark Twardowski says that "some of the sedative drugs have dose-dependent side effects, which means that the higher the dose, the more likely it is to get into trouble. suppressed respiratory function is a known side effect. "
The doctor and his colleagues in the emergency services noticed that more patients reported complaints about chronic nausea, a symptom that can occur from regular cannabis use. And they observed that some patients required much higher doses for general anesthesia and there were higher rates of postoperative seizures. It was this that led the doctor and his colleagues to collect data.
According to the study, Cannabis use in the US increased by 43% between 2007 and 2015. And he explains that as more states legalize medical and recreational cannabis, there is also a greater potential for the collection of significant data, since until now there was a lack of investigation due to the state of cannabis as a drug. Researchers believe that including specific questions about cannabis use to patient intake forms is the first step in obtaining useful information that influences care.
Dr. Twardowski says that "this study really marks a small first step, we still do not understand the mechanism behind the need for higher doses, which is important for finding better care management solutions." The doctor's team is now developing a follow-up study on the differences in sedation and anesthesia requirements, as well as post-procedure pain management for regular cannabis users versus non-users.